Facts and Importance of AB Negative Blood

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AB-negative blood is extremely rare, accounting for only one in every 10,000 newborn babies born each year.

The primary cause of AB-negative blood is the lack of the gene responsible for producing ABO blood group antigens. These antigens are produced by two genes: one on chromosome 9 and another on chromosome 4. If both genes are lacking, the individual will not make antigens.

But is AB-negative blood safe? What makes it unique? This blog contains solutions to all of these questions and many more.

What is the Rarest Blood Type?

Different blood kinds are common around the world. In the United States, the most frequent blood type is O-positive, while the rarest is AB-negative.


Less than 1% of Americans have the AB- blood type, making it an uncommon blood type in the country. All negative blood types are eligible to donate red blood cells to individuals with AB- negative blood types. If both parents have AB-negative blood, their children are likely to acquire the same characteristic.

AB-negative blood is not only rare but also very valued. It contains a variety of antibodies that help protect the body against disease-causing germs. A deficiency of these antibodies renders a person vulnerable to disease and infection.

The AB blood type contains antibodies, which are immune system cells that combat foreign invaders and illnesses. Blood types A, B, O, and AB have varying levels of each antibody.


AB Blood contains A and B antigens in its red blood cells. These antigens differentiate them from any other blood type. When someone receives their first immunization, they are given a dose of blood that contains these antigens. If they have been vaccinated previously, they will not react to the vaccination.

A person's immune system cannot fight off illnesses if they do not have the necessary antibodies. People with blood type AB produce more antibodies. This means they are less prone to become ill.

However, if someone becomes ill, their body produces more antibodies to protect them.


People who do not have AB blood need to receive transfusions. Only 1% of the people have AB blood type, making it the rarest body type.


Here are some less-known facts about AB-negative blood. 

1. AB-Negative blood is harmless to humans.

AB-negative blood is normal and does not carry any risks to human health. There have been instances where people born with AB-negative blood have developed leukaemia. However, these are rare cases. People with AB-negative blood do not need to worry about transfusions.

2. Less than 1% of people globally have Ab-negative blood.

Usually, 0.05% of the population has blood that is AB-negative. Not everyone's blood type is AB-negative. Northern Europe is a popular place to find AB-negative blood.

3. AB-Negative blood is one of the oldest blood types.

Blood kinds have existed for thousands of years. Ancient Egypt is home to the earliest known documentation of blood type. Three distinct blood kinds were identified by the Egyptians: O+, B-, and AB-. According to these documents, AB-negative blood was around before contemporary medicine.

There are many benefits to having AB negative blood. For one, it's scarce, making you a coveted donor.

●   AB negative blood is also the universal donor, meaning it can be given to any patient needing a transfusion. This is a huge benefit, especially in emergencies when time is of the essence.

●   AB negative blood also doesn't contain antibodies, so patients can receive multiple transfusions without developing harmful reactions.

●   AB negative blood is often used in emergencies because it's compatible with other blood types. And because it's so rare, there's always a demand for it. Only about 7% of the population has AB-negative blood, so it's always in high demand.

●   AB negative blood is also vital for medical research because it's the only blood type that can be used to create universal antibodies.

So if you have AB-negative blood, make sure to donate whenever you can! It could save someone's life.

What are the Risks of AB Negative Blood?

AB Negative blood is the blood that contains no antibodies (the body's defense mechanism).

There are many reasons why people have AB-negative blood, including genetics, immune system defects, and autoimmune disorders.

Having AB-negative blood does not mean you cannot get sick; however, if you do get sick, you may need to receive transfusions to help fight off infections.

Some people who have AB negative blood do not experience problems. However, some people with AB-negative red cells develop severe illness after receiving a blood transfusion.

Symptoms include fever, chills, nausea, vomiting, diarrhea, abdominal pain, and jaundice. People with AB negative blood should avoid donating blood unless they have been tested extensively before donation.

Ab-negative blood is rare, only occurring in 1 out of every 16,000 people. To receive AB-Negative blood, you would have to have parents who are both AB-Negative. If you do not have either AB- parent, you cannot receive AB- Blood.

How Can I Donate AB Negative Blood?

It's quite simple. You can donate blood at your local blood bank or donation centre. They'll test it to make sure it matches the patient's blood type, and then store it until needed.

If you'd like to donate blood or participate in medical research, please contact your local blood bank or medical centre. They would be happy to discuss with you about how you can help.

Here's the list of blood types in decreasing order of disease resistance: 

1. O Positive

The o-positive blood type is the most disease-resistant and serves as the universal donor. It is also the most common blood type in the world. People with o-positive blood have more antibodies, which help them fight bacteria and viruses.

2. A Positive

It is the second most prevalent blood type and is frequently connected with athletic individuals. These folks are stronger than others and have a higher chance of surviving heart attacks.

3. B Positive

Individuals with B-positive blood have a lower risk of diabetes. They are also more resistant to infections and have longer lifespans.

4. AB Negative

AB-negative blood comes in a variety of different forms. It is sometimes referred to as the universal recipient. Those with this blood type are considered rare and often have severe allergies.

5. RH Negative

Rh-negative blood is the least prevalent and has a higher aggression level. There are numerous fallacies surrounding RH-negative blood, including the belief that they are prone to mental illness and are unfit for sports.

People with AB-negative blood do get sick more often than others. But they still get sick less often than those with other blood types. Today, people with AB-negative blood live just as long as everyone else.

AB- and Sickle Anemia

People with AB negative blood are usually born without any signs of the disease. However, they may develop the disease if they inherit the trait from parents with the same blood type.

The risk of getting sickle cell anemia increases with each generation.

Many factors affect the likelihood of a child inheriting sickle cell anemia. These factors include the racial background of the parents, the mother's age when she gives birth, etc. Having AB negative blood is hereditary, meaning that people who carry the trait are carriers. As long as one parent carries the trait, there is a 50/50 chance their offspring will be affected by the disease.

Final Words

People with AB-negative blood cannot produce antibodies that fight bacteria. But don't worry! If you're AB-negative, you probably won't get sick much. 

Nowadays, medical technology has advanced significantly and has all the resources and treatments necessary to assist persons with AB- to enjoy long and healthy lives.

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